Comparative effects of low-carbohydrate diets high in protein and low in fat on the kidneys.
BACKGROUND AND OBJECTIVES:
Scientists are concerned about the deleterious effects on kidney diet to lose weight with low carb and intake of protein. This issue was addressed in a secondary analysis of a parallel, randomized, controlled long-term trial.
SCHEMA, ENVIRONMENT, PARTICIPANTS AND MEASURES:
Between 2003 and 2007, 307 obese adults without serious medical illness of three academic centers in the United States were randomly assigned to a diet low in carbohydrates and high in protein and low in fat in a diet to lose weight for 24 months. Main outcomes included renal filtration (GFR) indices (serum creatinine, cystatin C, creatinine clearance), the 24-hour urinary volume, albumin excretion of calcium and serum solutes at 3, 12 and 24 months.
RESULTS:
In comparison with the low-fat diet, low in carbohydrates and high in protein it was associated with minor reductions in serum creatinine (relative difference, -4.2%) and cystatin C (-8.4%) at 3 months and relative increases in creatinine clearance 3 (15.8 ml / min) and 12 (20.8 ml / min) months to three serum urea (14.4%), 12 (9.0%) and 24 (8.2%) months, and 24-hour urine volume to 12 (438 ml) and 24 (268 ml) months. Urinary excretion of calcium increased in 3 (36.1%) and 12 (35.7%) months without change in bone density or clinical presentations of new kidney stones.
CONCLUSIONS:
Obese people that are following a low carb and high protein diet for more than 2 years are in good health. This plan has not been associated with adverse effects on GFR, albuminuria or electrolyte balance compared to a low-fat diet on renal function.
Friedman, AN, Ogden, LG et al. (2012). Comparative effects of low-carbohydrate high-protein versus low-fat diets on the kidney. Clinical journal of the American Journal of Nephrology, 7(7) 1103-1111. http://www.ncbi.nlm.nih.gov/pubmed/22653255
Article published on http://www.dukandiet.co.uk/
Scientists are concerned about the deleterious effects on kidney diet to lose weight with low carb and intake of protein. This issue was addressed in a secondary analysis of a parallel, randomized, controlled long-term trial.
SCHEMA, ENVIRONMENT, PARTICIPANTS AND MEASURES:
Between 2003 and 2007, 307 obese adults without serious medical illness of three academic centers in the United States were randomly assigned to a diet low in carbohydrates and high in protein and low in fat in a diet to lose weight for 24 months. Main outcomes included renal filtration (GFR) indices (serum creatinine, cystatin C, creatinine clearance), the 24-hour urinary volume, albumin excretion of calcium and serum solutes at 3, 12 and 24 months.
RESULTS:
In comparison with the low-fat diet, low in carbohydrates and high in protein it was associated with minor reductions in serum creatinine (relative difference, -4.2%) and cystatin C (-8.4%) at 3 months and relative increases in creatinine clearance 3 (15.8 ml / min) and 12 (20.8 ml / min) months to three serum urea (14.4%), 12 (9.0%) and 24 (8.2%) months, and 24-hour urine volume to 12 (438 ml) and 24 (268 ml) months. Urinary excretion of calcium increased in 3 (36.1%) and 12 (35.7%) months without change in bone density or clinical presentations of new kidney stones.
CONCLUSIONS:
Obese people that are following a low carb and high protein diet for more than 2 years are in good health. This plan has not been associated with adverse effects on GFR, albuminuria or electrolyte balance compared to a low-fat diet on renal function.
Friedman, AN, Ogden, LG et al. (2012). Comparative effects of low-carbohydrate high-protein versus low-fat diets on the kidney. Clinical journal of the American Journal of Nephrology, 7(7) 1103-1111. http://www.ncbi.nlm.nih.gov/pubmed/22653255
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